Mechanobiology of Cell Reprogramming

Professor Song Li, University of California, Los Angeles
March 19, 2018 at 11:00 am
100 Busch Hall
Event Description 

Cell reprogramming into induced pluripotent stem cells or direct conversion of differentiated cells into a completely different lineage have wide applications in regenerative medicine, disease modeling and drug screening. Although the roles of transcriptional factors and chemical compounds in direct reprogramming have been widely studied, the effects of biophysical factors on cell reprogramming are not well understood. Here I will use the models of cell reprogramming into pluripotent stem cells, cardiomyocytes and neurons to demonstrate how the biophysical factors in the fluid phase and substrate (microtopography, stiffness) modulate the epigenetic state, transcriptional factors and mechanotransductive cellular structures and thus the reprogramming efficiency. Our findings provide insights into the roles of biophysical factors in regulating cell reprogramming and the underlying mechanism, which will open a new avenue for the rational design of smart biomaterials for cell reprogramming.