Faculty


	Dr. Mark R. Holland B.A., Kalamazoo College, 1981 M.A., Washington University, 1983 Ph.D., Washington University, 1989 (314) 935-6402 51 Compton

Summary of Dr. Holland's Research Activities Over Recent Years:

Clinical Ultrasonic Tissue Characterization:

Measurements of the systematic variation of backscattered energy from the myocardium over the heart cycle to characterize specific cardiac pathologies as well as providing an assessment of myocardial viability in patients undergoing dobutamine stress echocardiographic examinations.
Enhancements to methods for characterizing the variation of backscattered energy over the heart cycle in terms of its magnitude and time delay. Automated analysis software made available to the global research community via our Laboratory's web page.
Development and implementation of an RF data acquisition and analysis system on an ultrasonic imaging system permitting quantitative measurements of the backscattered ultrasonic properties of the hearts of patients.
Measurements of the spectral characteristics of backscattered ultrasound from excised tissues and developed quantitative methods of characterizing the spectral characteristics of backscattered ultrasound through an analysis of centroid frequencies and band-limited power ratios.
Development of an approach to measure the systematic variation of backscattered energy from the myocardium over the heart cycle of the right heart from children with congenital Tetralogy of Fallot or exhibiting Hypoplastic Left-Heart Syndrome.
Measurements of the ultrasonic backscatter and attenuation properties of the developing heart and their effects on echocardiographic imaging.

Myocardial Anisotropy:

Investigations to determine the role of the inherent anisotropic ultrasonic attenuation and backscatter of the heart in clinical echocardiography with an emphasis on determining its impact on quantitative imaging and the regional dependence of the systematic variation of backscattered energy over the heart cycle.
Experimental measurements of the regional dependence of backscattered ultrasonic energy for specific views of the hearts of normal human subjects and for excised tissues.
Comparisons between experimentally measured values of backscattered energy and the values predicted by a computer simulation of the parasternal short-axis view of the heart based on previously measured anisotropic acoustic properties of myocardium.
Measurements of the spectral characteristics of backscattered ultrasound from excised tissues as a function of the angle of ultrasonic beam insonification relative to the inherent fiber orientation.

High-Frequency Ultrasonic Measurements:

Development and implementation of a high-frequency ultrasonic measurement system capable of characterizing the ultrasonic properties of excised tissues in the 50 to 150 MHz range. This system can be used to assess ultrasonic properties of genetically-manipulated mouse hearts as well as biopsy specimens obtained during therapeutic interventions (e.g., surgery).
Measurement of the systematic variation of backscattered energy from the myocardium over the heart cycle of mouse hearts using a clinical imaging system in the 15 MHz range.

Ultrasonic Contrast Agents:

Studies investigating the relationship between the acoustic properties of ultrasonic contrast agents and the acoustic properties of myocardial tissue and how combinations of these properties affect quantitative assessments of regional myocardial perfusion with contrast echocardiography.
Implementation and utilization of ultrasonic methods to measure and characterize quantitatively the increase in backscattered ultrasonic energy due to myocardial perfusion with ultrasonic contrast agents in patients.

Harmonic Imaging and Nonlinear Ultrasound:

Comparisons of the measured variation of backscattered energy over the heart cycle obtained from the hearts of human subjects when imaged in the fundamental imaging mode with the corresponding values obtained while imaging the second harmonic mode.
Characterization of nonlinearly propagated ultrasonic fields and their relationship to the transmitted field.

Publications:

Dr. Mark R. Hollands's Publications

Education

1989	Ph.D., Washington University - St. Louis
1983	M.A., Washington University - St. Louis
1981	B.A., Kalamazoo College - Kalamazoo

Professional History:

2006-present	Research Associate Professor of Physics, Laboratory for Ultrasonics, Department of Physics, Washington University, St. Louis, MO
2005-present	Research Assistant Professor of Pediatrics, Division of Pediatric Cardiology, Washington University School of Medicine, Washington University, St. Louis, MO
2001-2006	Research Assistant Professor, Laboratory for Ultrasonics, Department of Physics, Washington University, St. Louis, MO
1990-2001	Research Scientist, Laboratory for Ultrasonics, Department of Physics, Washington University, St. Louis, MO
1989-1990	Research in Nondestructive Evaluation, Advanced Materials and Structures, McDonnell Aircraft Co., St. Louis, MO

Honors and Awards:

elected 1981	Phi Beta Kappa Honor Society
elected 2006	Fellow, American Institute of Ultrasound in Medicine

Professional Committee Memberships and Designations:

President, Missouri River Valley Chapter of the American Association of Physicists in Medicine, (2003 - 2004)
Chairman, Basic Science and Instrumentation Section, American Institute of Ultrasound in Medicine, (2002 - 2004)
Technical Standards Committee, American Institute of Ultrasound in Medicine, (2002 - present)
Membership Committee, American Institute of Ultrasound in Medicine, (2002 - 2004)
Designated liaison between American Association of Physicists in Medicine and the American Society of Echocardiography, (1998 - present)
Ultrasound Committee, American Association of Physicists in Medicine, (1997 - present)
Physics and Instrumentation Committee, American Society of Echocardiography, (1996 - 2001)
Chairman, St. Louis Section of the American Society for Nondestructive Testing, (1992 - 1994)

Address:

Mark R. Holland
Physics Department, CB 1105
Washington University
1 Brookings Drive
St. Louis, MO 63130-4899, USA

Phone:(314) 935-6402
Fax: (314) 935-5868
Office: 51 Compton